{"id":127807,"date":"2022-04-11T09:59:54","date_gmt":"2022-04-11T13:59:54","guid":{"rendered":"https:\/\/www.ucf.edu\/news\/?p=127807"},"modified":"2023-12-01T10:38:46","modified_gmt":"2023-12-01T15:38:46","slug":"ucf-developed-real-time-blood-monitor-saves-doctors-critical-time-during-surgery","status":"publish","type":"post","link":"https:\/\/www.ucf.edu\/news\/ucf-developed-real-time-blood-monitor-saves-doctors-critical-time-during-surgery\/","title":{"rendered":"UCF-developed Real-time Blood Monitor Saves Doctors Critical Time During Surgery"},"content":{"rendered":"<p>An <a href=\"https:\/\/www.ucf.edu\/healthcare\/\">innovative device developed by University of Central Florida and Orlando Health researchers<\/a> can save doctors critical time during life-or-death operations, like heart surgery.<\/p>\n<p>Their real-time blood monitor provides instant blood analysis to let surgeons know if a deadly problem in many surgeries \u2014 blood coagulation \u2014 is happening.<\/p>\n<p>Current tests can take up to 30 minutes, which is too long to wait on results when every second counts. This is especially important during surgery on the youngest patients, such as infants.<\/p>\n<p>The researchers\u2019 latest work, published recently in the journal <a href=\"https:\/\/pubs.rsc.org\/en\/Content\/ArticleLanding\/2022\/SM\/D1SM01726H\" rel=\"nofollow\"><em>Soft Matter<\/em><\/a>, is a numerical model that quantifies how the device works and adds further validation to its effectiveness.<\/p>\n<figure id=\"attachment_127812\" style=\"max-width: 200px;\" class=\"figure float-left\"><noscript><img decoding=\"async\" width=\"200\" height=\"300\" class=\"figure-img size-medium wp-image-127812 img-fluid\" src=\"https:\/\/www.ucf.edu\/news\/wp-content\/blogs.dir\/20\/files\/2022\/04\/DeCampl_for_web-200x300.jpg\" alt=\"Dr. William DeCampli\" srcset=\"https:\/\/www.ucf.edu\/wp-content\/blogs.dir\/20\/files\/2022\/04\/DeCampl_for_web-200x300.jpg 200w, https:\/\/www.ucf.edu\/wp-content\/blogs.dir\/20\/files\/2022\/04\/DeCampl_for_web-533x800.jpg 533w, https:\/\/www.ucf.edu\/wp-content\/blogs.dir\/20\/files\/2022\/04\/DeCampl_for_web-341x512.jpg 341w, https:\/\/www.ucf.edu\/wp-content\/blogs.dir\/20\/files\/2022\/04\/DeCampl_for_web-267x400.jpg 267w, https:\/\/www.ucf.edu\/wp-content\/blogs.dir\/20\/files\/2022\/04\/DeCampl_for_web-240x360.jpg 240w, https:\/\/www.ucf.edu\/wp-content\/blogs.dir\/20\/files\/2022\/04\/DeCampl_for_web.jpg 800w\" sizes=\"(max-width: 200px) 100vw, 200px\"><\/noscript><img decoding=\"async\" width=\"200\" height=\"300\" class=\"figure-img size-medium wp-image-127812 img-fluid lazyload\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%20200%20300%22%3E%3C%2Fsvg%3E\" alt=\"Dr. William DeCampli\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%20200%20300%22%3E%3C%2Fsvg%3E 200w\" sizes=\"(max-width: 200px) 100vw, 200px\" data-srcset=\"https:\/\/www.ucf.edu\/wp-content\/blogs.dir\/20\/files\/2022\/04\/DeCampl_for_web-200x300.jpg 200w, https:\/\/www.ucf.edu\/wp-content\/blogs.dir\/20\/files\/2022\/04\/DeCampl_for_web-533x800.jpg 533w, https:\/\/www.ucf.edu\/wp-content\/blogs.dir\/20\/files\/2022\/04\/DeCampl_for_web-341x512.jpg 341w, https:\/\/www.ucf.edu\/wp-content\/blogs.dir\/20\/files\/2022\/04\/DeCampl_for_web-267x400.jpg 267w, https:\/\/www.ucf.edu\/wp-content\/blogs.dir\/20\/files\/2022\/04\/DeCampl_for_web-240x360.jpg 240w, https:\/\/www.ucf.edu\/wp-content\/blogs.dir\/20\/files\/2022\/04\/DeCampl_for_web.jpg 800w\" data-src=\"https:\/\/www.ucf.edu\/news\/wp-content\/blogs.dir\/20\/files\/2022\/04\/DeCampl_for_web-200x300.jpg\"><figcaption class=\"figure-caption\">Study co-author Dr. William DeCampli is a pediatric cardiac surgeon at Orlando Health Arnold Palmer Hospital for Children and a professor of surgery in the Department of Clinical Sciences in UCF\u2019s College of Medicine.<\/figcaption><\/figure>\n<p>\u201cRight now, if we want to determine if the blood in a patient undergoing heart surgery is thin enough so that it won\u2019t form clots in the heart-lung machine, we have to draw blood from the patient periodically, throughout the entire operation, and then send it to a laboratory to get tested,\u201d says study co-author William DeCampli, a pediatric cardiac surgeon at Orlando Health Arnold Palmer Hospital for Children.<\/p>\n<p>\u201cThere are two problems there,\u201d says DeCampli, who is also a professor of surgery in the Department of Clinical Sciences in UCF\u2019s <a href=\"https:\/\/www.ucf.edu\/college\/medicine\/\">College of Medicine<\/a>. \u201cOne, we\u2019re drawing blood from a patient periodically, and if this patient is a newborn baby, it doesn\u2019t take much blood drawn to cause the baby to have a problem with blood loss. Secondly, when we send these tests away, it takes time to get the answer back, as much as 20 or 30 minutes. And that\u2019s too long.\u201d<\/p>\n<p>DeCampli has been working with Aristide Dogariu, a Pegasus Professor in UCF\u2019s <a href=\"https:\/\/www.ucf.edu\/college\/optics-photonics\/\">College of Optics and Photonics<\/a>, since 2017 to develop the blood monitor. The device has already successfully advanced through one clinical trial and is scheduled for a next clinical trial this year.<\/p>\n<figure id=\"attachment_127813\" style=\"max-width: 200px;\" class=\"figure float-right\"><noscript><img decoding=\"async\" width=\"200\" height=\"300\" class=\"figure-img size-medium wp-image-127813 img-fluid\" src=\"https:\/\/www.ucf.edu\/news\/wp-content\/blogs.dir\/20\/files\/2022\/04\/aristide_dogari_for_web-200x300.jpg\" alt=\"Aristide Dogariu\" srcset=\"https:\/\/www.ucf.edu\/wp-content\/blogs.dir\/20\/files\/2022\/04\/aristide_dogari_for_web-200x300.jpg 200w, https:\/\/www.ucf.edu\/wp-content\/blogs.dir\/20\/files\/2022\/04\/aristide_dogari_for_web-533x800.jpg 533w, https:\/\/www.ucf.edu\/wp-content\/blogs.dir\/20\/files\/2022\/04\/aristide_dogari_for_web-341x512.jpg 341w, https:\/\/www.ucf.edu\/wp-content\/blogs.dir\/20\/files\/2022\/04\/aristide_dogari_for_web-267x400.jpg 267w, https:\/\/www.ucf.edu\/wp-content\/blogs.dir\/20\/files\/2022\/04\/aristide_dogari_for_web-240x360.jpg 240w, https:\/\/www.ucf.edu\/wp-content\/blogs.dir\/20\/files\/2022\/04\/aristide_dogari_for_web.jpg 800w\" sizes=\"(max-width: 200px) 100vw, 200px\"><\/noscript><img decoding=\"async\" width=\"200\" height=\"300\" class=\"figure-img size-medium wp-image-127813 img-fluid lazyload\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%20200%20300%22%3E%3C%2Fsvg%3E\" alt=\"Aristide Dogariu\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%20200%20300%22%3E%3C%2Fsvg%3E 200w\" sizes=\"(max-width: 200px) 100vw, 200px\" data-srcset=\"https:\/\/www.ucf.edu\/wp-content\/blogs.dir\/20\/files\/2022\/04\/aristide_dogari_for_web-200x300.jpg 200w, https:\/\/www.ucf.edu\/wp-content\/blogs.dir\/20\/files\/2022\/04\/aristide_dogari_for_web-533x800.jpg 533w, https:\/\/www.ucf.edu\/wp-content\/blogs.dir\/20\/files\/2022\/04\/aristide_dogari_for_web-341x512.jpg 341w, https:\/\/www.ucf.edu\/wp-content\/blogs.dir\/20\/files\/2022\/04\/aristide_dogari_for_web-267x400.jpg 267w, https:\/\/www.ucf.edu\/wp-content\/blogs.dir\/20\/files\/2022\/04\/aristide_dogari_for_web-240x360.jpg 240w, https:\/\/www.ucf.edu\/wp-content\/blogs.dir\/20\/files\/2022\/04\/aristide_dogari_for_web.jpg 800w\" data-src=\"https:\/\/www.ucf.edu\/news\/wp-content\/blogs.dir\/20\/files\/2022\/04\/aristide_dogari_for_web-200x300.jpg\"><figcaption class=\"figure-caption\">Study co-author Aristide Dogariu is a Pegasus Professor in UCF\u2019s College of Optics and Photonics.<\/figcaption><\/figure>\n<p>The collaboration came about as the result of a meeting at UCF where DeCampli learned about Dogariu\u2019s work using light scattering from a laser to measure the thickness of various fluids and mixtures.<\/p>\n<p>Since then, the optics-based blood monitor has moved through in-lab testing and then a successful clinical trial, the results of which were published in <a href=\"https:\/\/www.ucf.edu\/news\/light-beam-replaces-blood-test-heart-surgery\/\"><em>Nature Biomedical Engineering<\/em><\/a>.<\/p>\n<p>The monitor uses an extremely small optical fiber that\u2019s a fraction of a millimeter in diameter to assess the status of the blood and can be inserted directly into the tubes of a heart-lung machine or in a catheter, without having to withdraw blood from the patient.<\/p>\n<p>In the latest study, the <a href=\"https:\/\/www.ucf.edu\/research\/\">researchers<\/a> demonstrated that they could quantify the mechanical properties of plasma that surrounds the red blood cells, which is key to describing the light fluctuations they use to determine if blood is beginning to coagulate.<\/p>\n<p>Their model was validated by optical microrheology measurements in laboratory-controlled conditions and in clinical environments involving both natural, intrinsic processes and external interventions.<\/p>\n<p>\u201cThe really nice thing about this current study is that Dr. Dogariu and his team were able to show that there is actually a fairly straightforward relationship between the measurements and two fundamental quantities that characterize the mechanical behavior of blood,\u201d DeCampli says.<\/p>\n<figure id=\"attachment_127815\" style=\"max-width: 1200px;\" class=\"figure mx-auto d-block\"><noscript><img decoding=\"async\" width=\"1200\" height=\"800\" class=\"figure-img img-fluid w-100 wp-image-127815 size-full\" src=\"https:\/\/www.ucf.edu\/news\/wp-content\/blogs.dir\/20\/files\/2022\/04\/Red_blood_cells_for_web.jpg\" alt=\"Red blood cells model\" srcset=\"https:\/\/www.ucf.edu\/wp-content\/blogs.dir\/20\/files\/2022\/04\/Red_blood_cells_for_web.jpg 1200w, https:\/\/www.ucf.edu\/wp-content\/blogs.dir\/20\/files\/2022\/04\/Red_blood_cells_for_web-300x200.jpg 300w, https:\/\/www.ucf.edu\/wp-content\/blogs.dir\/20\/files\/2022\/04\/Red_blood_cells_for_web-768x512.jpg 768w, https:\/\/www.ucf.edu\/wp-content\/blogs.dir\/20\/files\/2022\/04\/Red_blood_cells_for_web-600x400.jpg 600w, https:\/\/www.ucf.edu\/wp-content\/blogs.dir\/20\/files\/2022\/04\/Red_blood_cells_for_web-360x240.jpg 360w\" sizes=\"(max-width: 1200px) 100vw, 1200px\"><\/noscript><img decoding=\"async\" width=\"1200\" height=\"800\" class=\"figure-img img-fluid w-100 wp-image-127815 size-full lazyload\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%201200%20800%22%3E%3C%2Fsvg%3E\" alt=\"Red blood cells model\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%201200%20800%22%3E%3C%2Fsvg%3E 1200w\" sizes=\"(max-width: 1200px) 100vw, 1200px\" data-srcset=\"https:\/\/www.ucf.edu\/wp-content\/blogs.dir\/20\/files\/2022\/04\/Red_blood_cells_for_web.jpg 1200w, https:\/\/www.ucf.edu\/wp-content\/blogs.dir\/20\/files\/2022\/04\/Red_blood_cells_for_web-300x200.jpg 300w, https:\/\/www.ucf.edu\/wp-content\/blogs.dir\/20\/files\/2022\/04\/Red_blood_cells_for_web-768x512.jpg 768w, https:\/\/www.ucf.edu\/wp-content\/blogs.dir\/20\/files\/2022\/04\/Red_blood_cells_for_web-600x400.jpg 600w, https:\/\/www.ucf.edu\/wp-content\/blogs.dir\/20\/files\/2022\/04\/Red_blood_cells_for_web-360x240.jpg 360w\" data-src=\"https:\/\/www.ucf.edu\/news\/wp-content\/blogs.dir\/20\/files\/2022\/04\/Red_blood_cells_for_web.jpg\"><figcaption class=\"figure-caption\">The researchers&#8217; model of red blood cells in the blood is shown. Image credit: Jose Rafael Guzman-Sepulveda<\/figcaption><\/figure>\n<p>This is essential information that can be used as the technology moves its way toward widespread release, Dogariu says.<\/p>\n<p>\u201cWe developed a model that has been essentially confirmed by the experimental results that we have collected,\u201d he says. \u201cWe had the measurements that appear to be quite sensitive to real transformations in the bloodstream, but now we can put numbers to those changes.\u201d<\/p>\n<p>The work allows the researchers to, for the first time, relate their measurements to what was actually happening to the blood and explain the changes in the way that red blood cells \u201cjiggle\u201d around in the blood stream.<\/p>\n<p>\u201cThis is what we consider to be the next level in the development of this concept,\u201d Dogariu says.<\/p>\n<p>The researchers\u2019 next clinical trial will take place with pediatric patients, and then they hope to move into a series of clinical trials with adults. With continued success and funding, the researchers hope to see the blood monitor become available within the next five to seven years.<\/p>\n<p>Study co-authors also included Jose Rafael Guzman-Sepulveda, a graduate of UCF\u2019s <a href=\"https:\/\/www.ucf.edu\/degree\/optics-and-photonics-phd\/\">College of Optics and Photonics doctoral program<\/a> and now a researcher with the Center for Research and Advanced Studies of the National Polytechnic Institute in Mexico; and Mahed Batarseh and Ruitao Wu, graduate research assistants in UCF\u2019s College of Optics and Photonics.<\/p>\n<p>The research was funded by the U.S. National Institutes of Health.<\/p>\n<p>Dogariu received his doctoral degree in engineering from Hokkaido University in Sapporo, Hokkaido, Japan, and joined UCF in 1997.<\/p>\n<p>DeCampli received his doctoral degree in astrophysics from Harvard University and his doctor of medicine degree from the University of Miami. He completed residency in cardiac surgery at Stanford University and joined UCF\u2019s College of Medicine in 2009.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Current tests can take up to 30 minutes, which is too long when every second counts \u2014 especially during surgery on infants.<\/p>\n","protected":false},"author":66,"featured_media":127810,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"lazy_load_responsive_images_disabled":false,"footnotes":"","_links_to":"","_links_to_target":"","_wp_rev_ctl_limit":""},"categories":[5,23,24],"tags":[6395,979,1112],"tu_author":[],"class_list":["post-127807","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-colleges","category-research","category-science-technology","tag-aristide-dogariu","tag-college-of-medicine","tag-creol"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v22.3 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