{"id":134806,"date":"2023-04-18T11:57:13","date_gmt":"2023-04-18T15:57:13","guid":{"rendered":"https:\/\/www.ucf.edu\/news\/?p=134806"},"modified":"2023-04-21T09:33:19","modified_gmt":"2023-04-21T13:33:19","slug":"ucf-researchers-create-digital-map-of-sympathetic-nervous-system","status":"publish","type":"post","link":"https:\/\/www.ucf.edu\/news\/ucf-researchers-create-digital-map-of-sympathetic-nervous-system\/","title":{"rendered":"UCF Researchers Create Digital Map of Sympathetic Nervous System"},"content":{"rendered":"<p>A team of UCF College of Medicine researchers has created a digital topographical map of the cardiac sympathetic neural network, the region that controls the body\u2019s heart rate and its \u201cfight-or-flight\u201d response. They hope this map will eventually serve as a guide to treat cardiovascular conditions using bioelectronic devices.<\/p>\n<p>The study, led by Zixi Jack Cheng, a neuro-cardiovascular scientist, was published in the Scientific Reports journal and was the project of an <a href=\"https:\/\/www.ucf.edu\/research\/\">interdisciplinary team of researchers from UCF<\/a> along with several other institutions as well as industry partners MBF Bioscience and SPARC Data and Resource Center. The project has been supported by the NIH Common Fund\u2019s Stimulating Peripheral Activity to Relieve Conditions (SPARC) program, and funding from National Institute on Neural Disorders and Stroke and National Heart, Lung and Blood Institute.<\/p>\n<figure id=\"attachment_134808\" style=\"max-width: 1174px;\" class=\"figure mx-auto d-block\"><noscript><img decoding=\"async\" width=\"1174\" height=\"832\" class=\"figure-img img-fluid w-100 wp-image-134808 size-full\" src=\"https:\/\/www.ucf.edu\/wp-content\/blogs.dir\/20\/files\/2023\/04\/Sympathetic-Nervous-System-Map.jpg\" alt=\"A microscopic map of the heart\" srcset=\"https:\/\/www.ucf.edu\/wp-content\/blogs.dir\/20\/files\/2023\/04\/Sympathetic-Nervous-System-Map.jpg 1174w, https:\/\/www.ucf.edu\/wp-content\/blogs.dir\/20\/files\/2023\/04\/Sympathetic-Nervous-System-Map-300x213.jpg 300w, https:\/\/www.ucf.edu\/wp-content\/blogs.dir\/20\/files\/2023\/04\/Sympathetic-Nervous-System-Map-1129x800.jpg 1129w, https:\/\/www.ucf.edu\/wp-content\/blogs.dir\/20\/files\/2023\/04\/Sympathetic-Nervous-System-Map-722x512.jpg 722w, https:\/\/www.ucf.edu\/wp-content\/blogs.dir\/20\/files\/2023\/04\/Sympathetic-Nervous-System-Map-564x400.jpg 564w, https:\/\/www.ucf.edu\/wp-content\/blogs.dir\/20\/files\/2023\/04\/Sympathetic-Nervous-System-Map-360x255.jpg 360w\" sizes=\"(max-width: 1174px) 100vw, 1174px\"><\/noscript><img decoding=\"async\" width=\"1174\" height=\"832\" class=\"figure-img img-fluid w-100 wp-image-134808 size-full lazyload\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%201174%20832%22%3E%3C%2Fsvg%3E\" alt=\"A microscopic map of the heart\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%201174%20832%22%3E%3C%2Fsvg%3E 1174w\" sizes=\"(max-width: 1174px) 100vw, 1174px\" data-srcset=\"https:\/\/www.ucf.edu\/wp-content\/blogs.dir\/20\/files\/2023\/04\/Sympathetic-Nervous-System-Map.jpg 1174w, https:\/\/www.ucf.edu\/wp-content\/blogs.dir\/20\/files\/2023\/04\/Sympathetic-Nervous-System-Map-300x213.jpg 300w, https:\/\/www.ucf.edu\/wp-content\/blogs.dir\/20\/files\/2023\/04\/Sympathetic-Nervous-System-Map-1129x800.jpg 1129w, https:\/\/www.ucf.edu\/wp-content\/blogs.dir\/20\/files\/2023\/04\/Sympathetic-Nervous-System-Map-722x512.jpg 722w, https:\/\/www.ucf.edu\/wp-content\/blogs.dir\/20\/files\/2023\/04\/Sympathetic-Nervous-System-Map-564x400.jpg 564w, https:\/\/www.ucf.edu\/wp-content\/blogs.dir\/20\/files\/2023\/04\/Sympathetic-Nervous-System-Map-360x255.jpg 360w\" data-src=\"https:\/\/www.ucf.edu\/wp-content\/blogs.dir\/20\/files\/2023\/04\/Sympathetic-Nervous-System-Map.jpg\"><figcaption class=\"figure-caption\">The map may serve as a guide for treatments such as neuromodulation therapy \u2013 electronically stimulating nerves to treat cardiovascular conditions.<\/figcaption><\/figure>\n<p>\u201cThis mapping goes beyond what you can find in a textbook\u201d, Cheng says. \u201cThis is a digitized brain-heart atlas that will be interactive. We hope it will serve as a guide not only for scientists and physicians, but also for students as they learn the neuroanatomy of the heart.\u201d<\/p>\n<p>The map may serve as a guide for treatments such as neuromodulation therapy \u2013 electronically stimulating nerves to treat cardiovascular conditions.<\/p>\n<p>Cheng\u2019s team and his SPARC collaborators previously created a comprehensive 3D map of a rodent heart\u2019s intrinsic nervous system. The system, known as the \u201clittle heart brain,\u201d contains thousands of neurons around the heart that regulate heartbeat and blood circulation. Their latest project extended that study and mapped topographical network of the nerves in the sympathetic nervous system and its connection to the heart. &nbsp;The team hopes the advanced blueprint will help scientists and physicians to study the brain-heart connection and navigate more precise control of different heart regions including those that control the heartbeat.<\/p>\n<p>The sympathetic nervous system plays a pivotal role in regulating cardiac functions through an intricate network of nerves. It can help the body respond to dangerous or stressful situations, by speeding up the body\u2019s heart rate to deliver more blood to areas that need more oxygen. The system also controls the heart rate, blood pressure, digestion and other vital functions.<\/p>\n<p>To create the map, the team used a combination of state-of-the-art techniques to image, trace, digitize and quantitatively map the distribution of the sympathetic nervous system including the heart\u2019s whole atria and ventricles.<\/p>\n<p>\u201cThe groundbreaking part of this project is the precision at which the mapping is completed at the microscopic level which allows us to see the single cells and single nerve axons,\u201d Cheng says. &nbsp;This is the first time that scientists will see the whole organ at such an intricate level.\u201d<\/p>\n<p>Yuanyuan Zhang, the postdoctoral fellow in Dr. Cheng\u2019s lab, explained that this map will help researchers further test the functional role of a specific of nerve by activating or deactivating it and observing its impact on the body. &nbsp;He says the mapping can also serve as a guide for treatments such as neuromodulation therapy, which involves electronically stimulating nerves to treat cardiovascular conditions such as hypertension, sleep apnea and heart failure.<\/p>\n<p>\u201cUtilizing our map as a sympathetic-cardiac atlas opens the door for innovative therapies for several cardiovascular diseases, nerve-related disorders and avoids side effects associated with many pharmaceuticals,\u201d says Ariege Bizanti, a Ph.D. candidate in Cheng\u2019s lab.<\/p>\n<p>Heart disease is the leading cause of death for men and women in the United States, accounting for 697,000 deaths in 2020 according to statistics from the Centers for Disease Control. One person dies every 34 seconds in the United States from cardiovascular disease.<\/p>\n<p>\u201cThe cardiac-sympathetic nerve system is very complex and remains poorly understood,\u201d says Jin Chen, another UCF collaborator on the project. \u201cSo having this detailed mapping in the heart could give us important insights into the architecture of cardiac-sympathetic nerve and provide the foundation for future functional and molecular studies of sympathetic control of the heart.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>This digitized, interactive brain-heart atlas may serve as a guide for scientists and physicians, as well as students as they learn the neuroanatomy of the heart.<\/p>\n","protected":false},"author":57,"featured_media":134807,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"lazy_load_responsive_images_disabled":false,"footnotes":"","_links_to":"","_links_to_target":"","_wp_rev_ctl_limit":""},"categories":[12,23,24],"tags":[979,22543,14916],"tu_author":[],"class_list":["post-134806","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health","category-research","category-science-technology","tag-college-of-medicine","tag-healthcare","tag-research"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v22.3 (Yoast SEO v27.3) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>UCF Researchers Create Digital Map of Sympathetic Nervous System | University of Central Florida News<\/title>\n<meta name=\"description\" content=\"This digitized, interactive brain-heart atlas may serve 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