{"id":135141,"date":"2023-05-09T10:36:22","date_gmt":"2023-05-09T14:36:22","guid":{"rendered":"https:\/\/www.ucf.edu\/news\/?p=135141"},"modified":"2025-06-17T14:42:10","modified_gmt":"2025-06-17T18:42:10","slug":"new-ucf-developed-immunotherapy-treatment-targets-respiratory-viral-infections","status":"publish","type":"post","link":"https:\/\/www.ucf.edu\/news\/new-ucf-developed-immunotherapy-treatment-targets-respiratory-viral-infections\/","title":{"rendered":"New UCF-developed Immunotherapy Treatment Targets Respiratory Viral Infections"},"content":{"rendered":"

A University of Central Florida College of Medicine<\/a> researcher has developed a new, more precise treatment for a major cause of illness around the world each year \u2014 acute respiratory viral infections.<\/p>\n

Acute respiratory viral infections include sicknesses such as the flu, pneumonia, respiratory syncytial virus (RSV) and coronavirus. These infections cause millions of illnesses worldwide, with the flu alone responsible for 3 million to 5 million cases of severe illness and up to 650,000 respiratory deaths each year, according to the World Health Organization.<\/p>\n

The new treatment, which is now available for licensing<\/a>, uses immune system-related proteins known as cytokines in a controlled, targeted manner to fight infections and promote healing.<\/p>\n

\u201cInterventions that can improve the outcome of serious viral infection without interfering with effective anti-viral immune responses are urgently needed,\u201d says Tara Strutt, an assistant professor in the Burnett School of Biomedical Sciences<\/a> within UCF\u2019s College of Medicine, who developed the treatment.<\/p>\n

As a cellular immunologist, Strutt knows very well what cytokines \u2014 part of the body\u2019s defense against pathogens \u2014 can do.<\/p>\n

\u201cCytokines can do good things, and they can do bad things,\u201d she says. \u201cFor example, during severe infections, an overactive immune response can trigger a cytokine storm, a condition in which excess cytokine production leads to uncontrolled inflammation. This hyperinflammation can ultimately cause tissue damage and organ failure.\u201d<\/p>\n

The cytokine Strutt is using, interleukin-2 (IL-2), is currently approved for cancer immunotherapy. One of the challenges of IL-2-based therapy, though, is the numerous off-target effects that can result in organ and tissue damage, Strutt says.<\/p>\n

To overcome this, Strutt\u2019s immunotherapy treatment uses IL-2 combined with a monoclonal antibody specific for IL-2 to form an IL-2 antibody complex, or targeted IL-2. The targeted IL-2 can induce both anti-inflammatory and pro-inflammatory responses. By modulating inflammatory response, further complications such as cytokine storms can be avoided and clinical outcomes can be improved.<\/p>\n

In animal studies done in the Strutt laboratory, improved outcomes \u2014 including improved respiratory function and reduced airway inflammation \u2014 were seen when targeted IL-2 was administered during influenza virus infection. Targeted IL-2 was shown to promote an antiviral inflammatory response during viral infection and reduced, virtually absent, bronchial inflammation.<\/p>\n

Additionally, the use of the targeted IL-2 was shown to have a beneficial role in forming memory CD4 T-cells. These CD4 T-cells protect against pathogens previously encountered by infection or vaccination. This application has the potential to improve the immune responses stimulated by vaccines, Strutt says.<\/p>\n

About the Researcher<\/strong><\/p>\n

At UCF, Strutt is studying CD4 T-cells and how they function to protect against respiratory viruses, including Influenza A virus (IAV). The researcher and her team are also exploring how memory T cell responses function during pregnancy as pregnant females are at high risk for serious IAV infection associated complications.<\/p>\n

\u201cCD4 T-cells are the orchestrators of the immune response,\u201d she says.<\/p>\n

Also known as helper T-cells, CD4 T-cells produce and secrete specific cytokines that act as immune system messengers. During an IAV infection, subsets of CD4 T-cells become activated and start to produce and secrete IL-2, a potent T-cell growth factor with both proinflammatory and anti-inflammatory effects.<\/p>\n

Before joining UCF in 2015, Strutt was an assistant professor at the University of Massachusetts Medical School. She completed her postdoctoral work at the Trudeau Institute in New York and received her doctorate in immunology from the University of Saskatchewan.<\/p>\n

Her work, which stives to provide greater insight for the development of safe, innovative vaccine formulations and immune-based therapies for respiratory viral infections, is supported by a National Institutes of Health National, Institutes of Allergy and Infectious Diseases R01 award.<\/p>\n

Technology Available for License<\/strong><\/p>\n

To learn more about Strutt\u2019s work and additional potential licensing or sponsored research opportunities, contact Benjamin Neymotin (benjamin.neymotin@ucf.edu)<\/strong><\/a>\u00a0at 407.823.0665.<\/p>\n","protected":false},"excerpt":{"rendered":"

The treatment may be an effective and precise method for fighting viral infections including the flu, pneumonia, respiratory syncytial virus (RSV) and coronavirus, which cause millions of illnesses worldwide each year.<\/p>\n","protected":false},"author":66,"featured_media":135142,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"lazy_load_responsive_images_disabled":false,"footnotes":"","_links_to":"","_links_to_target":"","_wp_rev_ctl_limit":""},"categories":[5,23,24],"tags":[653,979,18082],"tu_author":[],"class_list":["post-135141","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-colleges","category-research","category-science-technology","tag-burnett-school-of-biomedical-sciences","tag-college-of-medicine","tag-health"],"yoast_head":"\nNew UCF-developed Immunotherapy Treatment Targets Respiratory Viral Infections | University of Central Florida 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