{"id":137113,"date":"2023-09-20T14:09:31","date_gmt":"2023-09-20T18:09:31","guid":{"rendered":"https:\/\/www.ucf.edu\/news\/?p=137113"},"modified":"2023-09-27T09:35:52","modified_gmt":"2023-09-27T13:35:52","slug":"ucf-researcher-receives-nih-grant-to-study-diets-role-on-side-effects-of-blood-cancer-treatment","status":"publish","type":"post","link":"https:\/\/www.ucf.edu\/news\/ucf-researcher-receives-nih-grant-to-study-diets-role-on-side-effects-of-blood-cancer-treatment\/","title":{"rendered":"UCF Researcher Receives NIH Grant to Study Diet&#8217;s Role on Side Effects of Blood Cancer Treatment"},"content":{"rendered":"<p>Every three minutes, someone in the U.S. is diagnosed with leukemia, lymphoma, or myeloma \u2014 which are cancers of the blood, bone marrow and lymph nodes.<\/p>\n<p>Treatments for blood cancers often require hematopoietic stem cell transplants but such cells can launch a potentially deadly immunological attack on the patient\u2019s organs called graft-vs-host disease (GVHD).\u00a0\u00a0With the help of a $2.75 million grant from the National Institutes of Health, <a href=\"https:\/\/www.ucf.edu\/college\/medicine\/\">UCF College of Medicine<\/a> researcher Hung Nguyen is examining how diet \u2014 particularly fat \u2014 affects GVHD in transplant patients.<\/p>\n<p>The disease comes in two forms. Acute GVHD usually occurs shortly after the transplant and can cause liver and digestive issues, a painful rash and even organ failure. Chronic GVHD can manifest months or years after the procedure. Symptoms vary among patients and can range from mild, such as dry eyes and fatigue, to irreversible organ damage. The condition can quickly advance from mild to severe in some chronic patients.<\/p>\n<p>\u201cAlthough life expectancy for patients with these cancers has increased with the help of donor stem cell transplantation, it\u2019s not without risk,\u201d says Nguyen. \u201cWhen the donor cells perceive the recipients\u2019 organs as foreign, chronic graft-versus-host disease develops.\u201d<\/p>\n<p>Previous studies have shown that diets containing high levels of long chain fatty acids such as fat, olive oil, soybean oil, etc. have been known to increase infections, length of hospital stays, respiratory distress syndrome and systemic inflammation in GVHD patients. Because of that, Nguyen is taking a closer look at the role of fatty acids in inflammation and transplant rejection.<\/p>\n<p>His team will study how medium chain fatty acid foods \u2014 such as coconut oil and avocados \u2014 affect the metabolism of donor cells of patients with chronic GVHD. He believes that a dietary approach to treatment could reduce or prevent the inflammatory reaction and lessen the patient\u2019s need for corticosteroids, which have had limited success at preventing permanent organ damage.<\/p>\n<p>\u201cThe goal of our current research project is to understand how medium chain fatty acid metabolism influences GVHD severity and mortality,\u201d he said.<\/p>\n<p>Blood cancers make up about 10% of the nation\u2019s diagnosed cancers each year.<\/p>\n<p>Nguyen\u2019s highly competitive R01 grant provides funding for five years from the NIH\u2019s National Heart, Lung and Blood Institute. He is collaborating with Stephanie Lee at Fred Hutchinson Cancer Center, Seattle and Nosha Farhadfar at the University of Florida.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Blood cancers make up about 10% of the nation\u2019s diagnosed cancers each year, and stem cell transplant treatments for these diseases can trigger immunological attacks for patients.<\/p>\n","protected":false},"author":57,"featured_media":137114,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"lazy_load_responsive_images_disabled":false,"footnotes":"","_links_to":"","_links_to_target":"","_wp_rev_ctl_limit":""},"categories":[12,17,23],"tags":[979,22543,54247,14916],"tu_author":[],"class_list":["post-137113","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health","category-medicine","category-research","tag-college-of-medicine","tag-healthcare","tag-hung-nguyen","tag-research"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v22.3 (Yoast SEO v27.5) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>UCF Researcher Receives NIH Grant to Study Diet&#039;s Role on Side Effects of Blood Cancer Treatment | University of Central Florida News<\/title>\n<meta name=\"description\" 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