{"id":64746,"date":"2015-03-06T10:34:56","date_gmt":"2015-03-06T15:34:56","guid":{"rendered":"https:\/\/www.ucf.edu\/news\/?p=64746"},"modified":"2025-06-17T14:35:19","modified_gmt":"2025-06-17T18:35:19","slug":"color-changes-everything-ucf-helps-develop-tool-aid-doctors-looking-cancer-clues","status":"publish","type":"post","link":"https:\/\/www.ucf.edu\/news\/color-changes-everything-ucf-helps-develop-tool-aid-doctors-looking-cancer-clues\/","title":{"rendered":"Color Changes Everything: UCF Helps Develop Tool to Aid Doctors Looking for Cancer Clues"},"content":{"rendered":"

Like real estate, gene expression is all about location, location, location \u2013 and a team of University of Central Florida researchers has just helped create a colored genetic map that doctors studying cancer can use to figure out how the disease works.<\/p>\n

Engineering associate professor Shaojie Zhang and graduate student Ardalan Naseri created a software program that mines the human genome for certain chromosomal-specific repeated sequences. The human genome is full of repeating patterns and while researchers know a lot about certain patterns and their biological functions, much remains unknown.<\/p>\n

UCF\u2019s team has designed a reliable software pipeline to find those repeated sequences that a University of Massachusetts Medical School team then used to start creating a color map to figure out exactly where chromosomes are within the human cell\u2019s nucleus \u2013 a mysterious and very tight-knit community. While the human genome project in 2001 revealed the human body\u2019s blueprint, how each part of that extensive blueprint works remains a mystery.<\/p>\n

Doctors Hanhui Ma and Thoru Pederson from the University of Massachusetts Medical School led the study, which looked to use the clustered, regularly interspaced short palindromic repeats (CRISPR) multicolor labeling system to further the understanding of the dynamics of human chromosomes and disease progression at 3-D genome level. \u00a0The team\u2019s work appeared online in the Proceedings of the National Academy of Sciences<\/a> on Feb. 23.<\/p>\n

Studying the nucleus of human cells is tough work because the center holds 23 chromosomal pairs that are the blueprint for the human body. Those chromosomes live in very tight bundles within the nucleus. Scientists have already linked several chromosome errors to specific birth defects, but they suspect that other smaller errors or mistakes in copying the pattern may be linked to other disease, such as cancer.<\/p>\n

\u201cOur goal was to find target sites with high copy numbers and certain repeat lengths, while taking into account that the target sequences should be specific for each location,\u201d said UCF\u2019s Zhang. \u201cWe have developed an efficient software pipeline to detect such target sites in the human genome.\u201d<\/p>\n

The CRISPR-based multicolor labeling system is relatively cheap, quick and accessible for researchers, Zhang said. The approach is an avenue for bar coding elements of the human genome.<\/p>\n

\u201cThis technology will provide a new toolkit for studying and monitoring the behavior of the nucleus in living cells,\u201d he said.<\/p>\n

Other authors of the study include Pablo Reyes-Gutierrez and Scot A. Wolfe from the University of Massachusetts Medical School.<\/p>\n

Zhang is an associate professor of computer science.\u00a0 He joined UCF in 2007 and runs the Computational Biology and Bioinformatics Group. He has several degrees including a Ph.D from the University of California at San Diego. He has had dozens of scholarly articles published and is currently work on a National Institutes of Health grant pertaining to RNA structural motifs.<\/p>\n","protected":false},"excerpt":{"rendered":"Like real estate, gene expression is all about location, location, location \u2013 and a team of University of Central Florida researchers has just helped create a colored genetic map that doctors studying cancer can use to figure out how the disease works. Engineering associate professor Shaojie Zhang and graduate student Ardalan Naseri created a software program that mines the human…","protected":false},"author":10,"featured_media":64747,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"template-twocol.php","format":"standard","meta":{"_acf_changed":false,"lazy_load_responsive_images_disabled":false,"footnotes":"","_links_to":"","_links_to_target":"","_wp_rev_ctl_limit":""},"categories":[5,6,23,24,27],"tags":[13399,973,1566,5942],"tu_author":[],"class_list":["post-64746","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-colleges","category-community","category-research","category-science-technology","category-student-life","tag-ardalan-naseri","tag-college-of-engineering-and-computer-science","tag-engineering","tag-shaojie-zhang"],"yoast_head":"\nColor Changes Everything: UCF Helps Develop Tool to Aid Doctors Looking for Cancer Clues | University of Central Florida 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