{"id":72682,"date":"2016-05-26T07:00:52","date_gmt":"2016-05-26T11:00:52","guid":{"rendered":"https:\/\/www.ucf.edu\/news\/?p=72682"},"modified":"2019-07-03T12:44:56","modified_gmt":"2019-07-03T16:44:56","slug":"technology-created-at-ucf-helps-cancer-researchers-monitor-genome","status":"publish","type":"post","link":"https:\/\/www.ucf.edu\/news\/technology-created-at-ucf-helps-cancer-researchers-monitor-genome\/","title":{"rendered":"Technology Created at UCF Helps Cancer Researchers Monitor Genome"},"content":{"rendered":"<p>Labeling and tracking multiple locations of the human genome in a live cell allows scientists to study structural changes in chromosomes and investigate cancer development.<\/p>\n<p>Finding optimal locations for labeling in the human genome is a challenging task due to the size of our genome. University of Central Florida associate professor Shaojie Zhang, working with researchers at the University of Massachusetts Medical School, is helping solve that problem. As <a href=\"https:\/\/www.nature.com\/articles\/nbt.3526?error=cookies_not_supported&amp;code=98892f5f-d3bb-4e58-ba48-a529a093f265\">published recently in <em>Nature Biotechnology<\/em><\/a>, Zhang has helped to develop a tool that allows biologists to zero in on particular genomic sequences they\u2019re researching.<\/p>\n<p>\u201cWe are trying to help them achieve that goal, because the human genome is extremely huge,\u201d said Zhang, an associate professor in the Department of Computer Science of the College of Engineering &amp;\u00a0Computer Science. \u201cWe have 3 billion letters, but they are not random; there\u2019s a lot of structure inside the human genome. The question is, can we assign an address for a certain location of a particular chromosome?\u201d<\/p>\n<p>A chromosome\u2019s position in a cell nucleus plays a role in our health and biology. By studying how they move within a nucleus, scientists hope to detect abnormalities that could shed light on how regular cells turn into cancer cells.<\/p>\n<p>Zhang\u2019s technology simplifies the task of finding appropriate targets to bar-code the genome. Those targets contain repetitive sequences that can be easily seen by binding what\u2019s known as the CRISPR\/Cas9 complex \u00a0with a pair of fluorescent proteins. This new tool, known as CRISPRainbow, can locate and track as many as seven different DNA sites by using seven different colors simultaneously.<\/p>\n<p>The software technology Zhang developed with his graduate student Ardalan Naseri builds on <a href=\"https:\/\/www.ucf.edu\/news\/color-changes-everything-ucf-helps-develop-tool-aid-doctors-looking-cancer-clues\/\">an earlier incarnation<\/a> that was able to track three colors. \u201cFrom a computer science point of view, it\u2019s about efficiently mining a long string based on certain criteria\u201d Zhang noted.<\/p>\n","protected":false},"excerpt":{"rendered":"Labeling and tracking multiple locations of the human genome in a live cell allows scientists to study structural changes in chromosomes and investigate cancer development. Finding optimal locations for labeling in the human genome is a challenging task due to the size of our genome. University of Central Florida associate professor Shaojie Zhang, working with researchers at the University of&hellip;","protected":false},"author":30,"featured_media":72683,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"template-twocol.php","format":"standard","meta":{"_acf_changed":false,"lazy_load_responsive_images_disabled":false,"footnotes":"","_links_to":"","_links_to_target":"","_wp_rev_ctl_limit":""},"categories":[5,23,24],"tags":[13399,973,12124,5942],"tu_author":[],"class_list":["post-72682","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-colleges","category-research","category-science-technology","tag-ardalan-naseri","tag-college-of-engineering-and-computer-science","tag-department-of-computer-science","tag-shaojie-zhang"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v22.3 (Yoast SEO v27.3) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>UCF 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