{"id":75712,"date":"2017-01-19T09:00:44","date_gmt":"2017-01-19T14:00:44","guid":{"rendered":"https:\/\/www.ucf.edu\/news\/?p=75712"},"modified":"2022-09-15T09:59:00","modified_gmt":"2022-09-15T13:59:00","slug":"nanoscience-medical-test","status":"publish","type":"post","link":"https:\/\/www.ucf.edu\/news\/nanoscience-medical-test\/","title":{"rendered":"New, Old Science Combine to Make Faster Medical Test"},"content":{"rendered":"

A UCF researcher has combined cutting-edge nanoscience<\/a> with a magnetic phenomenon discovered more than 170 years ago to create a method for speedy medical tests.<\/p>\n

The discovery, if commercialized, could lead to faster test results for HIV, Lyme disease, syphilis, rotavirus and other infectious conditions.<\/p>\n

\u201cI see no reason why a variation of this technique couldn\u2019t be in every hospital throughout the world,\u201d said Shawn Putnam, an assistant professor in the University of Central Florida\u2019s College of Engineering & Computer Science.<\/p>\n

At the core of the research recently published in the academic journal Small<\/em> are nanoparticles \u2013 tiny particles that are one-billionth of a meter. Putnam\u2019s team coated nanoparticles with the antibody to BSA, or bovine serum albumin, which is commonly used as the basis of a variety of diagnostic tests.<\/p>\n

By mixing the nanoparticles in a test solution \u2013 such as one used for a blood test \u2013 the BSA proteins preferentially bind with the antibodies that coat the nanoparticles, like a lock and key.<\/p>\n

That reaction was already well known. But Putnam\u2019s team came up with a novel way of measuring the quantity of proteins present. He used nanoparticles with an iron core and applied a magnetic field to the solution, causing the particles to align in a particular formation. As proteins bind to the antibody-coated particles, the rotation of the particles becomes sluggish, which is easy to detect with laser optics.<\/p>\n

The interaction of a magnetic field and light is known as Faraday rotation, a principle discovered by scientist Michael Faraday in 1845. Putnam adapted it for biological use.<\/p>\n

\u201cIt\u2019s an old theory, but no one has actually applied this aspect of it,\u201d he said.<\/p>\n

Other antigens and their unique antibodies could be substituted for the BSA protein used in the research, allowing medical tests for a wide array of infectious diseases.<\/p>\n

The proof of concept shows the method could be used to produce biochemical immunology test results in as little as 15 minutes, compared to several hours for ELISA, or enzyme-linked immunosorbent assay, which is currently a standard approach for biomolecule detection.<\/p>\n

Putnam collaborated with Richard J. Murdock, a 2015 UCF graduate who is now a doctoral student in the Harvard-MIT Health Science & Technology program; Soumen Das, Ankur Gupta and Sudipta Seal, all of UCF\u2019s Department of Materials Science and Engineering and the NanoScience Technology Center; and Elyse D.Z. Chase of the University of Pennsylvania.<\/p>\n","protected":false},"excerpt":{"rendered":"A UCF researcher has combined cutting-edge nanoscience with a magnetic phenomenon discovered more than 170 years ago to create a method for speedy medical tests. The discovery, if commercialized, could lead to faster test results for HIV, Lyme disease, syphilis, rotavirus and other infectious conditions. \u201cI see no reason why a variation of this technique couldn\u2019t be in every hospital…","protected":false},"author":30,"featured_media":75713,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"template-twocol.php","format":"standard","meta":{"_acf_changed":false,"lazy_load_responsive_images_disabled":false,"footnotes":"","_links_to":"","_links_to_target":"","_wp_rev_ctl_limit":""},"categories":[5,23,24],"tags":[973,3279,15761,4506],"tu_author":[],"class_list":["post-75712","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-colleges","category-research","category-science-technology","tag-college-of-engineering-and-computer-science","tag-nanoscience-technology-center","tag-pegasus-briefs","tag-sudipta-seal"],"yoast_head":"\nNew, Old Science Combine at UCF to Make Faster 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