{"id":77709,"date":"2017-06-05T09:41:08","date_gmt":"2017-06-05T13:41:08","guid":{"rendered":"https:\/\/www.ucf.edu\/news\/?p=77709"},"modified":"2018-07-02T14:19:01","modified_gmt":"2018-07-02T18:19:01","slug":"ucf-scientists-use-gene-editing-tech-develop-new-screening-tool-parkinsons-disease","status":"publish","type":"post","link":"https:\/\/www.ucf.edu\/news\/ucf-scientists-use-gene-editing-tech-develop-new-screening-tool-parkinsons-disease\/","title":{"rendered":"UCF Scientists Use Gene Editing Tech to Develop New Screening Tool for Parkinson&#8217;s Disease"},"content":{"rendered":"<p>A team of researchers at the University of Central Florida is using breakthrough gene-editing technology to develop a new screening tool for Parkinson\u2019s disease, a debilitating degenerative disorder of the nervous system. The technology allows scientists in the lab to \u201clight up\u201d and then monitor a brain protein called alpha-synuclein that has been associated with Parkinson\u2019s.<\/p>\n<p>\u201cAlpha-synuclein is a protein that is normally found in the brain. We all have it,\u201d said Burnett School of Biomedical Sciences doctoral student Levi Adams, one of the lead researchers on the project. \u201cBut for some reason, when you have Parkinson\u2019s the levels become abnormal. So, if we can monitor this protein in the cell, we can start to measure what causes it to go up and also what treatments can cause it to go down.\u201d<\/p>\n<p>The team published its findings in the <a href=\"https:\/\/www.nature.com\/articles\/srep45883?\"><em>Scientific Reports<\/em><\/a>\u00a0journal. The National Institutes of Health funded the work. The researchers believe their work is a crucial step toward identifying new drug therapies for Parkinson\u2019s disease.<\/p>\n<p>Adams is partnering with doctoral student Sambuddha Basu, associate professor and neurosciences researcher, Associate Professor Yoon-Seong Kim, and scientist Subhrangshu Guhathakurta to study Parkinson\u2019s, which affects motor functions caused by a gradual loss of brain cells. There are about 60,000 new cases of Parkinson\u2019s each year in the United States.<\/p>\n<p>They are using CRISPR Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats) gene-editing technology. The system is one of research\u2019s fastest growing biomedical techniques that allows scientists to make specific changes in the DNA of plants and animals while not killing cells. The system is becoming instrumental in studying genetically based treatments for diseases including cancer and Parkinson\u2019s.<\/p>\n<p>\u201cIt\u2019s the most powerful and widely used gene-editing technique in use because it allows us to change the DNA in living cells,\u201d said Kim, who is also a medical doctor. \u201cThe innovation of this method is that it enables us to monitor this gene in real-time without killing the cell. Without the CRISPR Cas-9 method, you would have to extract all the proteins from the cell to measure them, which kills the cell.\u201d<\/p>\n<p>Using the CRISPR technique, the Burnett team edited the alpha-synuclein gene and inserted a luminescent tag made from proteins that causes fireflies to light up. Every time the cell creates the alpha-synuclein protein, the tag gives off a light. That reaction \u201cmakes it much easier to measure,\u201d Adams said. \u201cMore light means an increased level of alpha-synuclein, which would be considered a diseased state.\u201d<\/p>\n<p>The team found that measuring light was a reliable method to measure alpha-synuclein production.<\/p>\n<p>\u201cIf we take one of these modified cells and treat it with a particular drug, if it doesn\u2019t produce light anymore, then this means the drug is a potential treatment for this disease,\u201d Basu said.<\/p>\n<p>With the engineered cells, researchers can screen new and existing drugs to see how they regulate alpha-synuclein level in patients.<\/p>\n<p>\u201cWith an easy-to-measure reporter like light production, this will allow us to do high throughput screening, where you can test a large panel of drugs at once,\u201d Guhathakurta said.<\/p>\n<p>With the new technology, the scientists\u00a0hope to identifying\u00a0ways to reduce alpha-synuclein production that can possibly prevent Parkinson\u2019s or its\u00a0progression in patients diagnosed with the disease.<\/p>\n<p>The team said research will focus on what aspects of the alpha-synuclein protein kill neurons during Parkinson\u2019s disease.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"A team of researchers at the University of Central Florida is using breakthrough gene-editing technology to develop a new screening tool for Parkinson\u2019s disease, a debilitating degenerative disorder of the nervous system. The technology allows scientists in the lab to \u201clight up\u201d and then monitor a brain protein called alpha-synuclein that has been associated with Parkinson\u2019s. \u201cAlpha-synuclein is a protein&hellip;","protected":false},"author":16,"featured_media":77711,"comment_status":"open","ping_status":"closed","sticky":false,"template":"template-twocol.php","format":"standard","meta":{"_acf_changed":false,"lazy_load_responsive_images_disabled":false,"footnotes":"","_links_to":"","_links_to_target":"","_wp_rev_ctl_limit":""},"categories":[5,6,12,27],"tags":[979,202],"tu_author":[],"class_list":["post-77709","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-colleges","category-community","category-health","category-student-life","tag-college-of-medicine","tag-alumni"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v22.3 (Yoast SEO v27.3) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ 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