{"id":96229,"date":"2019-04-16T10:45:14","date_gmt":"2019-04-16T14:45:14","guid":{"rendered":"https:\/\/www.ucf.edu\/news\/?p=96229"},"modified":"2019-04-17T10:49:32","modified_gmt":"2019-04-17T14:49:32","slug":"can-the-brain-help-heal-the-heart","status":"publish","type":"post","link":"https:\/\/www.ucf.edu\/news\/can-the-brain-help-heal-the-heart\/","title":{"rendered":"Can The Brain Help Heal The Heart?"},"content":{"rendered":"<p>A College of Medicine scientist is advancing research on how neurons in the heart<em>&nbsp;<\/em>communicate with the brain in hopes of using those messages to repair cardiac disease.<\/p>\n<p>Zixi Cheng, a neuro-cardiovascular researcher and doctor at UCF\u2019s <a href=\"https:\/\/med.ucf.edu\/biomed\/\">Burnett School of Biomedical Sciences<\/a>, recently received a $300,000 grant from the National Institutes of Health for his research on brain-heart interactions.<\/p>\n<p>Cheng\u2019s lab studies communication pathways of neurons \u2014 cells&nbsp;that send and receive information from the brain using electrical signals.<\/p>\n<p>Most of the body\u2019s 100 billion neurons are found in the brain, although some are located in the organs including the gut and the heart. Cheng explains that the heart\u2019s 4,000 to 5,000 neurons control the heartbeat and help the heart contract to circulate blood.<\/p>\n<blockquote><p>\u201cWe don\u2019t usually think about it, but the brain and the heart are closely connected as the central nervous system controls the heart.\u201d \u2014 Zixi Cheng, UCF neuro-cardiovascular researcher<\/p><\/blockquote>\n<p>\u201cWe don\u2019t usually think about it, but the brain and the heart are closely connected as the central nervous system controls the heart,\u201d Cheng says. \u201cJust think about when you\u2019re excited or nervous, how your heart beats faster, and when you relax it slows down.\u201d<\/p>\n<p>Because the body has billions of neurons, their individual locations and functions are unclear. That\u2019s why Cheng is developing a comprehensive topographical map that will show the body\u2019s neurons and their connection to the heart.<\/p>\n<p>\u201cOur research is trying to figure out how the nervous system is anatomically connected to the heart structure, by mapping the pathways of these neurons and identifying the their functions and how they control the heart,\u201d Cheng says.<\/p>\n<figure id=\"attachment_96236\" style=\"max-width: 1200px;\" class=\"figure\"><noscript><img decoding=\"async\" width=\"1200\" height=\"800\" class=\"figure-img size-full img-fluid w-100 wp-image-96236\" src=\"https:\/\/www.ucf.edu\/news\/wp-content\/blogs.dir\/20\/files\/2019\/04\/ucf-research-Cheng.jpg\" alt=\"Man wearing white coat and blue medical gloves sits at lab bench\" srcset=\"https:\/\/www.ucf.edu\/wp-content\/blogs.dir\/20\/files\/2019\/04\/ucf-research-Cheng.jpg 1200w, https:\/\/www.ucf.edu\/wp-content\/blogs.dir\/20\/files\/2019\/04\/ucf-research-Cheng-300x200.jpg 300w, https:\/\/www.ucf.edu\/wp-content\/blogs.dir\/20\/files\/2019\/04\/ucf-research-Cheng-768x512.jpg 768w, https:\/\/www.ucf.edu\/wp-content\/blogs.dir\/20\/files\/2019\/04\/ucf-research-Cheng-600x400.jpg 600w, https:\/\/www.ucf.edu\/wp-content\/blogs.dir\/20\/files\/2019\/04\/ucf-research-Cheng-360x240.jpg 360w\" sizes=\"(max-width: 1200px) 100vw, 1200px\"><\/noscript><img decoding=\"async\" width=\"1200\" height=\"800\" class=\"figure-img size-full img-fluid w-100 wp-image-96236 lazyload\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%201200%20800%22%3E%3C%2Fsvg%3E\" alt=\"Man wearing white coat and blue medical gloves sits at lab bench\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%201200%20800%22%3E%3C%2Fsvg%3E 1200w\" sizes=\"(max-width: 1200px) 100vw, 1200px\" data-srcset=\"https:\/\/www.ucf.edu\/wp-content\/blogs.dir\/20\/files\/2019\/04\/ucf-research-Cheng.jpg 1200w, https:\/\/www.ucf.edu\/wp-content\/blogs.dir\/20\/files\/2019\/04\/ucf-research-Cheng-300x200.jpg 300w, https:\/\/www.ucf.edu\/wp-content\/blogs.dir\/20\/files\/2019\/04\/ucf-research-Cheng-768x512.jpg 768w, https:\/\/www.ucf.edu\/wp-content\/blogs.dir\/20\/files\/2019\/04\/ucf-research-Cheng-600x400.jpg 600w, https:\/\/www.ucf.edu\/wp-content\/blogs.dir\/20\/files\/2019\/04\/ucf-research-Cheng-360x240.jpg 360w\" data-src=\"https:\/\/www.ucf.edu\/news\/wp-content\/blogs.dir\/20\/files\/2019\/04\/ucf-research-Cheng.jpg\"><figcaption class=\"figure-caption\">Zixi Cheng, a neuro-cardiovascular researcher and doctor at UCF\u2019s Burnett School of Biomedical Sciences, recently received a $300,000 grant from the National Institutes of Health for his research on brain-heart interactions.<\/figcaption><\/figure>\n<p>In mice models, Cheng injects different colored dyes into the heart so he can detect how heart neurons travel to the brain. Using a 3D-imaging system, Cheng\u2019s team is then able to create a digital, interactive 3D map illustrating the communication pathways.<\/p>\n<p>\u201cFollowing the pattern of movement of the dye, we are then able to map the pathways of the neurons as they send and receive signals from the brain to the heart,\u201d Cheng says.<\/p>\n<p>The goal is to develop better life-saving therapies for conditions such as heart failure and arrhythmia.<\/p>\n<p>\u201cIf we have a comprehensive mapping of nerves and we fully understand their anatomical structures and functions,\u201d Cheng says, \u201cthen we can possibly manipulate specific nerves to emit electrical signals to help repair the heart and effectively treat these heart conditions.\u201d<\/p>\n<p>Current studies are exploring therapies that modulate nerve signals as potential ways to treat conditions such as hypertension and heart failure with better recovery and survival rates.<\/p>\n<p>\u201cThere are several clinical trials going on, but some are not successful yet,\u201d Cheng says. \u201cSo that\u2019s why we\u2019re going back to basic science to better understand neurons\u2019 pathways and functions and this grant will help us to continue to do that.\u201d<\/p>\n<p>Cheng\u2019s grant is a sub-award from University of California, Los Angeles, the prime NIH SPARC recipient that leads a consortium of cardiology researchers from universities internationally participating in the research mission. SPARC, an acronym for&nbsp;Stimulating Peripheral Activity to Relieve Conditions, supports research into understanding nerve-to-organ interactions with the aim of developing better treatments for diseases and conditions.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A UCF College of Medicine scientist is advancing research on how neurons in the heart communicate with the brain in hopes of using those messages to repair cardiac disease.<\/p>\n","protected":false},"author":98,"featured_media":96234,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"lazy_load_responsive_images_disabled":false,"footnotes":"","_links_to":"","_links_to_target":"","_wp_rev_ctl_limit":""},"categories":[12,17],"tags":[979,14916],"tu_author":[],"class_list":["post-96229","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health","category-medicine","tag-college-of-medicine","tag-research"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v22.3 (Yoast SEO v27.3) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Can The Brain Help Heal The Heart?<\/title>\n<meta name=\"description\" content=\"A UCF College of Medicine scientist is advancing research on how neurons in the heart communicate with the brain in hopes of using those messages to repair cardiac disease.\" 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