Whether it’s solving the world’s biggest problems or investigating the potential of novel discoveries, researchers at UCF are on the edge of scientific breakthroughs that aim to make an impact. Through the Research in 60 Seconds series, student and faculty researchers condense their complex studies into bite-sized summaries so you can know how and why Knights plan to improve our world.
Name: Dinender Singla
Position(s): Professor of medicine; head of the Division of Metabolic and Cardiovascular Sciences; AdventHealth endowed chair of cardiovascular sciences
Why are you interested in this research?
My research journey began more than 30 years ago, while pursuing my doctorate, with a focus on developing molecular-based diagnostic tests for the early detection of rheumatic fever and rheumatic heart disease. Over time, this foundation evolved as I collaborated with cardiovascular clinicians and basic scientists, deepening my commitment to creating innovative technologies that can meaningfully improve patient outcomes. Despite substantial global investment in heart disease treatment, mortality rates remain unacceptably high. Closing this gap continues to motivate my work and inspires me to find solutions. My ultimate goal is to develop transformative, science-driven therapies that not only improve clinical care but also save the lives of millions affected by cardiovascular disorders.
Who inspires you to conduct your research?
My mother has always been my strongest source of inspiration. She often shared stories about my maternal uncle and cousin, both of whom earned doctoral degrees. They sparked my early curiosity for scientific discovery. Though she was a homemaker, she was remarkably intelligent, forward-thinking and active. The values she instilled in me — hard work, persistence and creativity — continue to guide my scientific pursuits. Her passing from diabetes and diabetic cardiomyopathy profoundly strengthened my commitment to advancing cardiovascular research. Beyond her, my wife has been my greatest supporter, constantly motivating me to pursue ambitious scientific goals. These remarkable individuals have shaped my journey and empowered me to achieve all that I have accomplished in my research career.
How does UCF empower you to do your research?
I joined UCF in June 2007, coming from the University of Wisconsin and the University of Vermont, when the College of Medicine was still emerging and biomedical research was in its early stages. Making this move came with questions and uncertainties, even from colleagues who were hesitant about my decision. But I was driven by the desire to help build something unique and make a meaningful contribution at a new institution.
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Throughout my journey, there were moments when challenges made me consider leaving. However, the support I received from Deborah German, dean of the College of Medicine and vice president for health affairs, reinforced my commitment to stay and grow here. As a clinician, German deeply understands the value of research and ensures I have the resources to succeed. More recently, Griff Parks, professor and director of the Burnett School of Biomedical Sciences, has continued that support by providing the guidance and facilities essential to advancing my research. His perspective as an accomplished researcher allows him to recognize exactly what is needed for success in this field.
UCF has also been an exceptional environment for finding talented, motivated students. I am deeply grateful for the support of my outstanding students, colleagues, staff and administration, all of whom have been instrumental to my success.
What major grants and honors have you earned to support your research?
I have secured more than $12 million in research funding from the National Institutes of Health to support a broad portfolio of innovative cardiovascular studies. Throughout my career, I’ve also been honored with numerous awards recognizing my scientific contributions. One of the most meaningful distinctions has been my appointment as the AdventHealth endowed chair of cardiovascular sciences, which reflects both the impact of my work and my vision for advancing cardiovascular research.
Why is this research important?
Cardiovascular disease remains the leading cause of death worldwide and imposes a significant economic burden on healthcare systems. Despite major advances in medicine, millions of patients still die each year because current diagnostic tools and therapies often fail to precisely target diseased heart tissue. Many treatments require patients to take multiple high-dose medications, yet clinicians cannot be certain that these drugs are effectively reaching the heart, limiting efficacy and increasing the risk of side effects.
My research directly addresses this critical challenge by developing an innovative, targeted drug delivery platform to transform cardiovascular therapy. Our goal is to create a safe, highly targeted treatment strategy that improves patient outcomes, reduces healthcare costs and lowers global cardiovascular mortality rates — all while advancing a more personalized, effective approach to heart disease care.
