A College of Medicine scientist is advancing research on how neurons in the heart communicate with the brain in hopes of using those messages to repair cardiac disease.
Zixi Cheng, a neuro-cardiovascular researcher and doctor at UCF’s Burnett School of Biomedical Sciences, recently received a $300,000 grant from the National Institutes of Health for his research on brain-heart interactions.
Cheng’s lab studies communication pathways of neurons — cells that send and receive information from the brain using electrical signals.
Most of the body’s 100 billion neurons are found in the brain, although some are located in the organs including the gut and the heart. Cheng explains that the heart’s 4,000 to 5,000 neurons control the heartbeat and help the heart contract to circulate blood.
“We don’t usually think about it, but the brain and the heart are closely connected as the central nervous system controls the heart.” — Zixi Cheng, UCF neuro-cardiovascular researcher
“We don’t usually think about it, but the brain and the heart are closely connected as the central nervous system controls the heart,” Cheng says. “Just think about when you’re excited or nervous, how your heart beats faster, and when you relax it slows down.”
Because the body has billions of neurons, their individual locations and functions are unclear. That’s why Cheng is developing a comprehensive topographical map that will show the body’s neurons and their connection to the heart.
“Our research is trying to figure out how the nervous system is anatomically connected to the heart structure, by mapping the pathways of these neurons and identifying the their functions and how they control the heart,” Cheng says.
In mice models, Cheng injects different colored dyes into the heart so he can detect how heart neurons travel to the brain. Using a 3D-imaging system, Cheng’s team is then able to create a digital, interactive 3D map illustrating the communication pathways.
“Following the pattern of movement of the dye, we are then able to map the pathways of the neurons as they send and receive signals from the brain to the heart,” Cheng says.
The goal is to develop better life-saving therapies for conditions such as heart failure and arrhythmia.
“If we have a comprehensive mapping of nerves and we fully understand their anatomical structures and functions,” Cheng says, “then we can possibly manipulate specific nerves to emit electrical signals to help repair the heart and effectively treat these heart conditions.”
Current studies are exploring therapies that modulate nerve signals as potential ways to treat conditions such as hypertension and heart failure with better recovery and survival rates.
“There are several clinical trials going on, but some are not successful yet,” Cheng says. “So that’s why we’re going back to basic science to better understand neurons’ pathways and functions and this grant will help us to continue to do that.”
Cheng’s grant is a sub-award from University of California, Los Angeles, the prime NIH SPARC recipient that leads a consortium of cardiology researchers from universities internationally participating in the research mission. SPARC, an acronym for Stimulating Peripheral Activity to Relieve Conditions, supports research into understanding nerve-to-organ interactions with the aim of developing better treatments for diseases and conditions.